TRCC (Texas Regional CTSA Consortium) Quantitative Seminar Series
“Evaluating Community-Based Translational Interventions Using Historical Controls: Propensity Score vs. Disease Risk Score Approach”
Luohua Jiang, Ph.D.
Associate Professor- Department of Epidemiology
University of California, Irvine
Tuesday, September 29, 2020 Noon – 1 pm Virtual (Zoom)
This seminar contributes to achieving one or more of the CTSA core competencies in the category of Statistical Approaches.
Abstract: Many community-based translations of evidence-based interventions are designed as one-arm studies due to ethical and other considerations. Evaluating the impacts of such programs is challenging. Here we examine the effectiveness of the lifestyle intervention implemented by the Special Diabetes Program for Indians Diabetes Prevention (SDPI-DP) demonstration project, a translational lifestyle intervention among American Indian and Alaska Native communities. Data from the landmark Diabetes Prevention Program placebo group was used as a historical control. We compared the use of propensity score (PS) and disease risk score (DRS) matching to adjust for potential confounder imbalance between groups. The unadjusted hazard ratio (HR) for diabetes risk was 0.35 for SDPI-DP lifestyle intervention vs. control. However, when relevant diabetes risk factors were considered, the adjusted HR estimates were attenuated toward 1. The differences in estimated HRs using the PS and DRS approaches were relatively small but DRS matching resulted in more participants being matched and smaller standard errors of effect estimates. Carefully employed, publicly available randomized clinical trial data can be used as a historical control to evaluate the intervention effectiveness of one-arm community translational initiatives. It is critical to use a proper statistical method to balance the distributions of potential confounders between comparison groups in this kind of evaluations.
Participating TRCC Institutions include: UTMB, UTHSC-Houston, UTHSC-San Antonio, and UT Southwestern
For Zoom Meeting information please contact Casey Sendejas