Roberto P. Garofalo, M.D., who holds numerous UTMB titles, including Sealy and Smith Professor of Pediatrics and Vice Chair for Research in the Department of Pediatrics, and who is the PI of the Bronchiolitis Multidisciplinary Translational Team, received an award of $8,786,017 for a competitive renewal of a program project grant P01 AI062885 entitled “Epithelial Innate Signaling in Airway Inflammation and Remodeling.” Dr. Garofalo will serve as Program Director/PI for the overall project.
The central theme of this P01 is that innate inflammation produced by infection with the ubiquitous RSV impairs antioxidant capacity, producing disease and triggering long-term airway remodeling. This P01 will identify mechanisms of innate signaling-induced remodeling and develop strategies for reversing remodeling and restoring defective innate immunity in allergic airway diseases. Translational advances include applications of BRD4 inhibitors, NRF2 agonists, and OGG1 inhibitors that in preclinical studies show promise to interfere with RSV-induced inflammation and remodeling.
The three research projects within the grant are:
- RP1 - Epigenetic regulation of innate inflammation-driven airway remodeling (led by Allan R. Brasier, M.D., executive director of the University of Wisconsin’s Institute for Clinical and Translational Research & senior associate dean for clinical and translational research at UW’s School of Medicine and Public Health)
- RP2 - The role of innate immunity in downregulation of the airway antioxidant response during paramyxovirus infection (led by Antonella Casola, M.D., Professor, Department of Pediatrics, UTMB)
- RP3 - Linkage of the oxidant induced OGG1-DNA complex to airway inflammation and remodeling (led by Istvan Boldogh, Ph.D., Professor, Department of Microbiology and Immunology, UTMB)