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UTMB Proteomics Center

Serving as the home for one of seven newly awarded national Proteomics Centers funded by the NHLBI, the Biomolecular Resource Facility at UTMB brings the power of multiple analytical technologies to proteomics research. The UTMB NHLBI Center for Airway Inflammation consists of a multi-disciplinary team of scientists and physician-scientists to study protein expression associated with signaling pathways important in airway inflammation. In addition, the Center is engaged in the development of innovative technologies for application to proteomics research. It is the result of an NHLBI initiative to establish centers to enhance and develop innovative proteomics technologies and apply them to biological questions relevant to heart, lung, blood, and sleep health and disease.

LabPeople300wThe Biomolecular Resource Facility (BRF) is a UTMB designated core facility providing research support targeted to the analysis of biomolecules, especially proteins and peptides. The initial organization of the BRF began in 1975 and the facility has grown considerably over the years to meet the analytical needs of biomedical investigators. Dr. Alexander Kurosky, has been the Director of this facility since its inception.

The overarching philosophy of the BRF is to provide UTMB researchers with a menu of services encompassing state-of-the-art analytical capabilities and technologies at reasonable costs that will enhance their funded research projects as well as the quality of their publications. Investigators are encouraged to interact closely with BRF personnel to obtain maximum benefit of the BRF services. Technologies and the available instrumentation in the BRF are at the cutting edge of research. The BRF is committed to provide expert analyses, and Core personnel have been well-trained and are highly skilled in their analytical duties. In order to ensure quality of services, the BRF Cores participate in the ABRF's annual analytical testing evaluations using identical samples distributed to all member facilities.

Contact Us

Galveston, Texas
Biomolecular Resource Facility

1.106 Libbie Moody Thompson Basic Science Building
301 University Boulevard
Galveston, Texas 77555-0635

Phone: (409) 772-8085
FAX: (409) 772-8025

Proteomics Bioinformatics Core

As part of the Proteomics Section of the Biomolecular Resource Facility and consistent with its mission, the goal of the Proteomics Bioinformatics Core is to assist researchers at UTMB in their analyses of gels and other proteomics separation technologies.

  • The Protein Bioinformatics Core provides informatics tools, including statistical tools, for the analysis of 1D and 2D electrophoresis gels utilizing a software suite from Totallab (formerly Nonlinear Dynamics) and sample tracking, data management and access tools, using software from GenoLogics (Proteus LIMS). The BRF is a major Nonlinear and GenoLogics partner and collaborates with these manufacturers in the development of their software.
  • The Bioinformatics Core interacts extensively with other BRF Cores, and UTMB Centers and Departments and has integrated the Progenesis software into high-end user groups. For example, the BRF has installed the Editor Progenesis software at a number of sites across the UTMB campus.
  • Group training sessions are scheduled as needed, typically every six months.


Mass Spectrometry Core

The aim of the UTMB Mass Spectrometry Core (MSC) is to assemble state-of-the-art instrumentation and highly skilled technical staff to provide experimental capabilities required to support a broad range of molecular-level research. Mass spectrometry (MS) plays an increasingly important role in molecular-level research, and it is central to ‘omics’ research.  The MSC is well-equiped to facilitate studies with a suite of LC-MS systems including the ThermoScientific Fusion Orbitrap MS, the Sciex 5600 TripleTOF, 6500 Qtrap, and 5800 MALDI TOF/TOF.

  • Molecular weight determination of biomolecules such as lipids, metabolites, peptides and proteins.
  • Protein identification from gel plugs or bands and solutions using enzymatic digestion followed by MS or MS/MS using either MALDI or LCMS.
  • Proteomics: identification of large numbers of proteins from complex mixtures using LCMS. Can include quantitative measurements.
  • Identification of post-translational modifications.
  • Differential quantitation by label-free (DIA, DDA, or SWATH), iTRAQ, TMT, or SILAC using the Thermo Orbitrap Fusion or Sciex 5600+ TripleTof.
  • Quantitation of molecules using Selected Reaction Monitoring (SRM) or multi-reaction monitoring (MRM) on a 6500 QTrap.
  • Advanced informatics from proteomics datasets: Beyond Mascot and Sequest output.


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