ITS Health Informatics - i2b2

The Institute for Translational Sciences provides Informatics for Integrating Biology and the Bedside (i2b2) as an open-source application that allows rapid identification of patient cohorts within data from the Epic- Electronic Medical Record (EMR) and other sources at UTMB. Originally developed by an NIH-funded National Center for Biomedical Computing (NCBC) based at Partners HealthCare System in Boston, MA, this platform enjoys wide international adoption by the CTSA network, academic health centers, and industry.


Since all of the data is de-identified, users do not need prior IRB approval to access the system for feasibility studies. However, to release patient level data UTMB requires IRB approval for research studies. If you need help preparing an IRB submission or retrieving patient level information, please feel free to contact us for assistance.

Please see our Exempt Determination document for what is exempt from IRB review.

We recommend the i2b2 platform for special projects only and encourage users to look into ACT/SHRINE or TriNetX for their de-identified data searches.

We also recommend that users receive training on the use of i2b2. One on one training and group training are available to faculty and their staff.

If your project meets the requirements above, you may submit a request for services at

***NEW*** We are excited to announce that we are now part of the Accrual in Clinical Trials (ACT) research network that will enable data sharing and increase network capacity between CTSA institutions.  ACT includes over 37 institutions in the CTSA program and contains more than 100 million patients. Use of the network will allow UTMB investigators to perform i2b2 queries over the entire ACT network to guide the design and recruitment for multi-site clinical studies. For more information about ACT, visit the ACT Network Homepage.

Specific uses of i2b2 include:

  • Identifying a population for clinical trials,
  • Identifying geographic areas for clinical trial recruitment,
  • Quick "what if's" - for example where you are trying to link a drug to a procedure or diagnosis,
  • Eliminate manual chart reviews for many data request types - resulting in increased efficiency and data accuracy,
  • Federated queries for discovery research across multiple institutions.

Who can use it? (Open to anyone at UTMB.)

How do I get access? You can submit a request for services at

Find your Trusted Requestor here!

To learn more about i2b2, visit

Contact: or x72872 (CTSA)